• Formation of micelles that protect the lipid cannabinoids and allow for sable oil droplets encapsulated into the micelles that have sizes ranging from just above 100nm to about 350nm.
• This increases absorption because in order to absorb lipids/oils the body produces enzymes that break down giant oil droplets into smaller ones and encapsulates them into micelles, which takes time and energy and in the end, only 4%-5% of the oil gets absorbed. But if the oil is ingested already micellized, the body does not need to do all that work, so the absorption happens much faster and more of the oil gets absorbed.

Microemulsion Pros

• Higher lipid payload (up to 20%)
• Better Organoleptics
• Safer from the liver

Microemulsion Cons

• Opaque
• Less bioavailable than the nano-emulsion
• Slightly less stable than the nano-emulsion

Nano-Emulsion Pros

• Transparent/Translucent
• High bioavailability
• Superb stability

Nano-Emulsion Cons

• Lower lipid payload (1%-10%)
• Very bitter taste
• Liver toxicity risk in case of overdose depending on the lipid

Mile High Labs’ 20%  CBD water soluble liquid contains 200,000mg/L or 200mg/mL. 

Typical 5%  water soluble liquid contains 50,000mg/L or 50mg/mL. In comparison the concentration of 10% or 20% will drastically decrease the overall cost for end product formulation. 

Can liners are essential in CBD-infused beverages to ensure the stability and potency of the product. Without a proper liner, CBD can adhere to the sides of the can, reducing its effectiveness and leading to an inconsistent dosage. Additionally, high-quality can liners help maintain the taste and texture of the beverage by preventing CBD from separating and settling. This ensures that each sip provides the intended benefits and a consistent experience for consumers.

CBD oil by itself is very bitter and the smaller its droplet size the more bitter it becomes, simply because it is more bioavailable. This means optimizing the droplet size to be not too large (to avoid absorption issues), but also not too small (to avoid organoleptic issues).

There are several methods involving nanotechnology that manufacturers can use to make CBD water-soluble or dispersible. The most common methods involve breaking down the large CBD oil droplets into smaller droplets using the process of ultrasonic cavitation, or high-pressure homogenization.

Water-solubility refers to the ability of a substance to be dispersed in water. CBD is an oil. This can create problems when it comes to its bioavailability, or the degree to which it can be absorbed and used by the body, or in how it mixes into or stays in a consistent solution within a beverage. The reason for that is because 60%-70% of the human body is made of water, or is hydrophilic, hence water-soluble compounds are easily absorbed in the body.

CBD Isolate & Vitamin D3 Water Soluble Liquid is a revolutionary microemulsion liquid concentrate that synergizes the powerful benefits of CBD Isolate with the essential nutrient Vitamin D3. This innovative formulation, featuring a potent blend of 20% CBD Isolate and an optimal dose of Vitamin D3, is expertly designed for seamless integration into a variety of beverages, enhancing their nutritional value due to high bioavailability. Vitamin D3 is celebrated for its critical role in supporting bone health, immune function, and overall well-being. Similar to our esteemed CBD Isolate Water Soluble Liquid, this new variant offers the same ease of use for manufacturers, aiming to enrich consumer products with the combined advantages of CBD and Vitamin D3 for a healthier lifestyle

Mile High Labs CBD Isolate with Ashwagandha Water Soluble Liquid is an advanced microemulsion liquid concentrate that combines the wellness benefits of Ashwagandha Root Extract, known for its exceptional purity and sustainable extraction process, with the therapeutic properties of CBD. This unique formulation, containing 20% CBD and 5% Ashwagandha, is designed to integrate seamlessly into beverages, contributing to their health benefits. The CBD and Ashwagandha Water Soluble Liquid maintains similar characteristics as our flagship Water Soluble CBD Isolate, ensuring ease of use for manufacturers.

Key Specifications:

• 20% CBD | 5% Ashwagandha
• CBD Per 1L 200,000 mg/L or 200mg/mL
• Ashwagandha Per 1L 50,000 mg/L or 50mg/mL

Essential for Bone Health

• Attribute: Vitamin D3 is crucial for calcium absorption, key to enhancing bone density and preventing conditions like osteoporosis, particularly important for women as they age.
• Study Links: Mayo Clinic on Vitamin D | Royal Osteoporosis Society |
• CBD Synergy: CBD may reduce inflammation around joints and bones, enhancing the bone health benefits provided by Vitamin D3.

Mood Enhancement

• Attribute: Vitamin D3 has been linked to mood stabilization and reducing symptoms of mood disorders, especially vital in regions with limited sunlight exposure.
• Study Links: Harvard School of Public Health on Vitamin D | NHS on Vitamin D
• CBD Synergy: The calming effects of CBD may further aid in alleviating stress and anxiety, offering a comprehensive approach to mood regulation.

Supports Immune Function

• Attribute: Vitamin D3 plays a significant role in immune system health by helping to modulate the body’s immune responses.
• Study Links: Harvard School of Public Health on Vitamin D | NHS on Vitamin D
• CBD Synergy: CBD supports the immune system through its anti-inflammatory properties, enhancing the robust immune-boosting effects of Vitamin D3.

Cortisol Regulation and Weight Management

• Attribute: Regulating cortisol levels is a potential benefit of Vitamin D3, which may help manage weight gain linked to stress.
• Study Link: Dr. Berg on the Interplay Between Vitamin D and Cortisol
• CBD Synergy: CBD is recognized for its potential to reduce stress, which can aid in managing cortisol levels and support weight management.

Geographic Need for Supplementation

• Attribute: In areas with significant periods of low sunlight, such as the UK and Northern Europe, Vitamin D3 supplementation is essential to prevent deficiency.
• Study Links: Harvard School of Public Health on Vitamin D | New Review on Vitamin D Intake in the UK
• CBD Synergy: The anti-inflammatory and mood-stabilizing effects of CBD complement Vitamin D3, enhancing overall wellness in regions with less sun exposure.

Supports Immune Function and COVID-19 Resistance

• Attribute: Vitamin D3 has been shown to play a crucial role in modulating the immune system, which is essential for fighting infections, including COVID-19.
• Study Links: ISRAEL21c on Vitamin D and COVID-19
• CBD Synergy: The anti-inflammatory properties of CBD support the immune system, potentially enhancing the protective effects of Vitamin D3 against respiratory infections.

* The recommended daily limit for Vitamin D3 intake is set at 4,000 IU (International Units), with a recommended daily intake of 600 IU for healthy adults. It is important to adhere to this upper limit to maintain optimal health and prevent potential adverse effects associated with excessive intake.

• Age 0-12 months – 10 micrograms (mcg) (400 IU)
• Age 1-70 years – 15 mcg (600 IU)
• Age 71 and over  – 20 mcg (800 IU)